Discuss the promising varieties of pharmaceutical intermediates in detail

At present, pharmaceutical intermediates manufacturers discuss the most promising pharmaceutical intermediates mainly as follows:

Nucleoside intermediates: The main anti - AIDS drug synthesized by this intermediate is zidovudine, which is produced by Glaxo Wellcome and Bristol-Myers Squibb in the United States.

Cardiovascular intermediates: For example, synthetic sartan drugs have become widely used in the treatment of hypertension because of their more thorough antihypertensive effect, fewer side effects, long efficacy (can stably control blood pressure for 24 hours) and can be used in combination with other sartan drugs. According to statistics, in 2015, the global demand for major sartan drug APIs (losartan potassium, olmesartan ester, valsartan, irbesartan, telmisartan, candesartan ester) reached 3300 tons. Total sales were $21.063 billion.

Fluorinated intermediates: Fluorine-containing drugs synthesized from these intermediates have been developed rapidly in recent years because of their excellent efficacy. Representative products, such as fluoroquinolone anti-infective drugs, antidepressant fluoxetine and anti-fungal drug fluconazole, account for a relatively high proportion in clinical use. In addition, trifluoroethanol is an important intermediate in the synthesis of anesthetics, and trifluoromethylaniline is an important intermediate in the synthesis of antimalarial drugs, anti-inflammatory and analgesic drugs, anti-prostate drugs, antidepressants, market prospects are also very broad.

Heterocyclic intermediates: Represented by pyridine and piperazine, it is mainly used in the synthesis of anti-ulcer drugs, large stomach drugs, anti-inflammatory anti-infective drugs, high-efficiency antihypertensive drugs and anti-breast cancer new drug letrozole.

Shanghai Massive Chemical Technology Co., Ltd. is engaged in development, production and marketing Specialty Chemicals to satisfy the changing needs of the chemical industry. We specialize in manufacturing high quality of Advanced Intermediates, Special Fine chemicals, synthesis of novel and known molecular compounds, have substantial experience in process development, scale up and commercialization. 

Dimethylthiocarbamoyl chloride is an organosulfur compound with the formula (CH3)2NC(S)Cl. A yellow solid, it is often encountered as a yellow syrup. It is a key reagent in the synthesis of arylthiols via the Newman-Kwart rearrangement. Dimethylthiocarbamoyl chloride was used in chemoselective deoxygenation of pyridine-N-oxides. It was used in the synthesis of (±)-thia-calanolide A. It was used as starting reagent in the synthesis of dimethylthiocarbamates.