The so-called pharmaceutical intermediates are actually some chemical raw materials or chemical products used in the process of drug synthesis. These chemicals, which do not require a pharmaceutical manufacturing license, can be produced in ordinary chemical plants and can be used in the synthesis of medicines as long as they reach a certain grade.
First, most of the production enterprises are private enterprises with flexible operation and small investment scale, basically ranging from millions to 10 to 20 million yuan; Second, the geographical distribution of production enterprises is relatively concentrated, mainly distributed in taizhou, Zhejiang province and Jintan, Jiangsu province as the center of the region; Third, with the increasing attention of the country to environmental protection, the pressure of manufacturing enterprises to build environmental protection treatment facilities increases; Fourth, the product update speed is fast. After a product is put on the market for 3 to 5 years, its profit margin will drop sharply, which forces the enterprise to constantly develop new products or improve the production process, in order to maintain high production profit; Fifth, because the production profit of pharmaceutical intermediates is higher than chemical products, the production process of the two is basically the same, so there are more and more small chemical enterprises to join the production of pharmaceutical intermediates, leading to increasingly fierce disordered competition in the industry; Sixth, compared with active pharmaceutical substances, the profit margin of the production of intermediates is low, and the production process of active pharmaceutical substances is similar to that of pharmaceutical intermediates. Therefore, some enterprises have not only produced intermediates, but also started to produce active pharmaceutical substances by taking advantage of their own advantages.
Dimethylthiocarbamoyl chloride was used in chemoselective deoxygenation of pyridine-N-oxides. It was used in the synthesis of (±)-thia-calanolide A. It was used as starting reagent in the synthesis of dimethylthiocarbamates.
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