Preparation method and application of Dimethylthiocarbamoyl chloride

2021-08-05 Shanghai Massive Chemical

Heterocyclic compounds are organic compounds that contain Heterocyclic structures in their molecules. The atoms of the ring contain at least one heteroatom in addition to the carbon atom. Heterocyclic compound is the largest group of organic compounds. The most common heteroatoms are nitrogen, sulfur, and oxygen. It can be divided into two categories: lipid heterocyclic and aromatic heterocyclic. Heterocyclic compounds are ubiquitous in the structure of drug molecules.

Dimethylthiocarbamoyl chloride is a heterocyclic compound. Dimethylthiocarbamoyl chloride is used in organic compounds and as pharmaceutical intermediates

Dimethylthiocarbamoyl chloride is colorless crystal. Dimethylthiocarbamoyl chloride dissolves in ether, chloroform and petroleum ether.

Properties of Dimethylthiocarbamoyl chloride

Melting point: 39-43°C(lit.)

Boiling point: 90-95°C/0.5mmHg(lit.)

Density: 1.204(estimate)

Refractive index: 1.6100(estimate)

Flashing point: 209°F

Storage condition: 2-8°C

Solubility: SolubleinchloroformandtetraChemicalbookhydrofuran.

Acid value: (pKa)0.30±0.50(Predicted)

State: Low melting crystalline solidor crystals

Color: slightly yellow to yellow

Water solubility: reacts

Sensitivity: MoistureSensitive

Dimethylthiocarbamoyl chloride is synthesized from the reaction of thiocarbamoyl Chloride with Chloride in carbon tetracloride. Firstly, carbon tetrachloride is used to absorb chlorine gas at low temperature to prepare chlorine carbon tetrachloride solution. Tetramylthulam disulfide and carbon tetracloride were then stirred into a suspension and heated back in a water bath. The above solution of chlorine carbon tetrachloride is quickly added. After adding, half of the carbon tetracloride is evaporated, and the sulfur is filtered out after cooling. The filtrate was further concentrated and then distilled under reduced pressure to obtain the finished product at 65-68℃ (26.7Pa) with a yield of 80%.

Shanghai Massive Chemical Technology Co., Ltd. is engaged in development, production and marketing Specialty Chemicals to satisfy the changing needs of the chemical industry. We specialize in manufacturing high quality of Advanced Intermediates, Special Fine chemicals, synthesis of novel and known molecular compounds.

Shanghai Massive Chemical Technology Co., Ltd. have substantial experience in process development, scale up and commercialization of Dimethylthiocarbamoyl chloride.

Dimethylthiocarbamoyl chloride was used in chemoselective deoxygenation of pyridine-N-oxides. It was used in the synthesis of (±)-thia-calanolide A. It was used as starting reagent in the synthesis of dimethylthiocarbamates.

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