Dimethylthiocarbamoyl chloride, a kind of pharmaceutical intermediate

Dimethylthiocarbamoyl chloride is a kind of pharmaceutical intermediate. The so-called pharmaceutical intermediates are actually some chemical raw materials or chemical products used in the process of drug synthesis. The chemical, which does not require a pharmaceutical production license, can be produced in a regular chemical plant, as long as it reaches a certain level, and can be used in the synthesis of drugs.

Dimethylthiocarbamoyl chloride was used in chemoselective deoxygenation of pyridine-N-oxides. It was used in the synthesis of (±)-thia-calanolide A. It was used as starting reagent in the synthesis of dimethylthiocarbamates.

Properties of Dimethylthiocarbamoyl chloride

China needs more than 2,000 kinds of raw materials and intermediates supporting the chemical industry every year, and the demand is more than 2.5 million tons. After more than 30 years of development, China's pharmaceutical production of chemical raw materials and intermediates basically can be matched, only a small part of the need to import. And because China's resources are relatively rich, raw material prices are low, there are many intermediates to achieve a large number of exports.

Throughout the whole industry, China's pharmaceutical intermediates production has six characteristics:

1. The production enterprises are mostly private enterprises with flexible operation and small investment scale, basically between millions and 20 million yuan;

2. The regional distribution of production enterprises is relatively concentrated, mainly distributed in Taizhou of Zhejiang Province and Jintan of Jiangsu Province;

3. As the country pays more and more attention to environmental protection, the pressure on the production enterprises to build environmental protection treatment facilities increases;

4. Product update speed is fast. A product is generally on the market 3~5 years later, its profit margin will be greatly reduced, which forces the enterprise must constantly develop new products or constantly improve the production process, in order to maintain a high production profit;

Dimethylthiocarbamoyl chloride, a kind of pharmaceutical intermediate

5. As the production profit of pharmaceutical intermediates is higher than that of chemical products, and the production process of both are basically the same, more and more small chemical enterprises have joined the ranks of pharmaceutical intermediates production, leading to increasingly fierce competition in the industry;

6. Compared with API, the profit margin of producing intermediates is low, and the production process of API and pharmaceutical intermediates is similar. Therefore, some enterprises have not only produced intermediates, but also started to produce API by taking advantage of their own advantages.